About Me

PhD Student | Epidemiology & Biostatistics
Population and Quantitative Health Sciences
Case Western Reserve University

I'm a Ph.D. student in Epidemiology and Biostatistics in the Department of Population and Quantitative Health Sciences (PQHS) at Case Western Reserve University. I am in the laboratory of Dr. Dana Crawford, a genetic epidemiologist and Professor in PQHS and the Cleveland Institute for Computational Biology, whose current research interests map to the intersection of big data biomedical informatics and genomics. My research focus broadly addresses the critical gaps in knowledge of how information is encoded into DNA and how the story, when changed, leads to human disease using emerging statistical and bioinformatic approaches. I am interested in developing novel methods using electronic health records and the high-throughput sequencing data for translational research, with a particular focus on neurocognitive phenotypes (e.g., Alzheimer's disease). I hope that my work could enrich the knowledge of the disease etiology and identify more opportunities for tailored prevention, intervention, and treatment strategies based on individual patient clinical and 'omic data. Please find the information below, along with my CV (using the link on the right side), for more details.

Outsides of research, I am a foodie and a superfan for detective fiction. Always passionate to solve the puzzle, “the truth, is always curious and beautiful to seekers after it”.


  • PhD in Epidemiology and Biostatistics (in progress)

    Case Western Reserve University

  • MS in Biomedical Engineering (2017)

    Carnegie Mellon University

  • BS in Biological Sciences (2016)

    Fudan University

    The University of Hong Kong (Exchange Study in 2014)

  • Research Interests

    My research interests focus on characterizing common and rare genetic variants associated with human diseases.

    • Developing statistical and bioinformatics approaches for characterizing the genetic architecture of complex diseases
    • Identifying pleiotropy and environmental modifiers of genetic associations
    • Using electronic health records for translational research


    Longitudinal changes in T-cell receptor sequence diversity in minimal change disease.

    Characterized the T-cell receptor repertoire profiles for patients with minimal change disease both during active disease and complete remission, and worked on identifying T-cel receptor beta-chain amino acid sequences unique to the active disease status.

    Single-Cell Sequencing for Fragile X Syndrome (FXS) Forebrain Organoids

    Analyzed the gene expression of the FXS forebrain organoids at the single-cell level, in which the differential expressed genes and the conservative marker genes were obtained for each cluster, and the single-cell pseudo-time trajectories were constructed to show the altered developmental trajectory in a cell type-specific manner.

    Changes of Hippocampal Neuropeptide Y (NPY) Protein Expression after Controlled Cortical Impact (CCI)

    Identified the associations among long-term alterations of NPY expression in multiple targeting subfields of hippocampi, CCI treatment, and posttraumatic epileptogenesis adjusting for injury severity.

    Publications & Honors


    Journal Articles Awards
    • Diana Jacobs Kalman/AFAR Scholarships for Research in the Biology of Aging.


    Conference Presentations, Invited Talks, & Workshops
    • Liu, S. Longitudinal changes in T-cell receptor sequence diversity in minimal change disease. American Society of Human Genetics (ASHG).
    • Summer Institute in Statistical Genetics (SISG) Scholarship at the University of Washington.


    Journal Articles

    Contact Me

    Feel free to contact me!